Amid his best game since returning from a PCL injury, San Francisco 49ers receiver Ricky Pearsall not only reinjured the knee Sunday but suffered a low ankle sprain.

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran quarterback Philip Rivers will get his chance at redemption.

Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.

After starting the season with a 10-4 record, the San Francisco 49ers take on the Indianapolis. Here's a look at the betting odds for the matchup.

Indianapolis Colts' head coach Shane Steichen confirmed on Monday that Phillip Rivers will start in next week's game against the San Francisco 49ers on Monday Night football. This announcement by Steichen doesn't come as a surprise. In Rivers' return to action against Seattle, he provided needed stability at the quarterback position.

The 49ers' offense is about the same as 2024. The defense is worse. The special teams, though, has taken a historic leap. Is it sustainable?

The San Francisco 49ers could be getting some unexpected speed injected into their receiving corps late in the 2025 season.

This article originally published at The 49ers' perpetual Achilles' heel is now making history.