Cytochrome P450 enzymes constitute a highly diverse superfamily that is pivotal in the metabolism of endogenous and exogenous compounds. In the context of cancer research, members such as CYP1B1 and ...

The cytochrome P450 enzymes form a vast superfamily of haem‐containing monooxygenases that catalyse the metabolism of a broad spectrum of endogenous substances and xenobiotics. Their dynamic catalytic ...

January 15, 2008 — A recent statement from the Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group summarized scientific evidence regarding the value of cytochrome P450 ...

Phase I study of docetaxel and temsirolimus in refractory solid tumors. Background: Interactions of cytochrome P450 (CYP), especially CYP3A4, between chemotherapy agents and other xenobiotics can ...

September 25, 2012 (Phoenix, Arizona) — Patients with chronic pain who require high doses of opioids to achieve pain relief show exceptionally high rates of defects of the cytochrome P450 (CYP450) ...

Phase II study to evaluate efficacy and safety of irinotecan, capecitabine, and bevacizumab in patients with metastatic colorectal cancer (mCRC). This is an ASCO Meeting Abstract from the 2011 ASCO ...

As you know, the liver does much more than cope with the alcoholic aftermath of the Friday afternoon happy hour at your lab. The members of the cytochrome P450 superfamily of enzymes, the “worker bees ...

To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide ...

ARABIDOPSIS THALIANA CYTOCHROME P450 REDUCTASE1 (ATR1) and ATR2 provide electrons from NADPH to a large number of CYTOCHROME P450 (CYP450) enzymes in Arabidopsis (Arabidopsis thaliana). Whereas ATR1 ...

Assessment of cytochrome P450 (CYP450) inhibition is now performed early in drug development to decrease thelikelihood of progressing a compound with the potential to cause drug-drug interactions.

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...