UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of ...

Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.

Researchers can use messenger RNA to trigger the immune system to attack tumors. By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT (MA, ...

Hepatocellular carcinoma (HCC), the most common primary liver cancer, poses a global health threat with over 680,000 new diagnoses and 620,000 deaths annually. Current immunotherapies often fail due ...

cGAS-STING signaling exerts antitumor functions in cancer cells in an autonomous and non-autonomous manner. On the one hand, OIS secretes SASP in response to oncogenic stimuli to prevent cell ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The study demonstrated that inducing cancer cells to ...

When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team wanted to identify other transcription factors regulated by STING. On ...