The production of biotherapeutics involves many unit operations, and it is common practice to store in-process material as dictated by the manufacturing setup and scheduling of unit operations. The ...

Monoclonal antibody expression systems typically utilise a signal peptide to ensure secretion of the antibody into the cell culture medium. Although this reduces the complexity of purification and ...

Recombinant proteins can be produced using many types of cells including, yeast, bacteria, insect and mammalian cells. What advantages are there to producing recombinant proteins using mammalian cells ...

Optimizing the clarification of cell culture or fermentation broth is generally seen as a limited contributor to critical quality attributes (CQA). Researchers at Merck, however, say it’s time to ...

The 3M Harvest RC clarifier condenses three process steps into a single-stage purification of recombinant protein therapeutics. The 3M Harvest RC clarifier from 3M Health Care uses a proprietary ...

Monoclonal antibodies (mAbs) are an important class of therapeutics. In recent years, however, increased attention has been devoted to the development of next-generation biologic therapeutics and ...

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