Efflux pumps in Gram-negative bacteria actively export antibiotics out of the cell, and their overexpression can confer multidrug resistance. Two new studies explore the effect of the overexpression ...

Acinetobacter baumannii is a Gram-negative opportunistic pathogen responsible for severe hospital-acquired infections worldwide. Its ability to survive desiccation and adhere to medical devices ...

Monoclonal antibody-based therapies for hematologic malignancies. For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the cell, potentially be metabolized to an ...

It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of ...

To the Editor: Khera et al. (Jan. 13 issue) 1 report that cholesterol efflux from macrophages was a marginally better predictor of coronary artery disease than high-density lipoprotein (HDL) ...

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

Scientists at the University of Cambridge have uncovered the final piece in the jigsaw revealing the structure of ‘efflux pumps’, which allow Salmonella and other disease-causing bacteria to develop ...