The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...

Now, in a study published March 30 in Cell Chemical Biology, UB scientists have shed light on one such stressor, showing that ...

Study identifies impaired ER-to-golgi ceramide transport as a key regulatory node underlying senescence-associated sphingolipid remodeling.

An international team, including scientists from Leipzig University, has gained important new insights into the regulation of ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes, transporters, ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as ...

“A lot of what we’ve assumed based on the tools that we had really isn’t true,” study coauthor Craig Blackstone, a cell biologist at the National Institute of Neurological Disorders and Stroke, told ...

Within aging organisms, cells slowly lose their youthful precision: Membranes stiffen, repair systems malfunction, and proteins begin to misfold and pile up. One of the cell organelles that ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as ...

Ceramide buildup due to faulty transport triggers stress responses that lock cells into senescence, revealing a potential ...