Animals depend on their sense of smell to locate food, identify mates and evade danger. In mammals, olfactory perception typically relies on G protein–coupled receptor (GPCR) pathways. Insects, by ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

Signal transduction is a key mechanism that brings about several physiological responses in a cell. Aberrant signaling can result due to gene mutations or regulatory protein overexpression. It is ...

Johns Hopkins Medicine researchers say they have evidence to potentially overturn a prevailing belief in a type of important signaling within cells. The mainstream idea is that a single protein ...

SEATTLE--(BUSINESS WIRE)--Omeros Corporation (Nasdaq: OMER) today announced a new approach to cancer immunotherapy that targets inhibition of GPR174, a member of the family of G protein-coupled ...

Using advanced imaging methods, researchers have gained insight into how a common target of drugs sends cellular signals, a finding that may lead to better and more precise therapeutics. Roughly a ...

While investigating why cholesterol-lowering drugs called statins cause negative side effects such as blurred vision, short-term memory loss or increased risk for diabetes, cellular chemists at The ...