A French research team led by CNRS scientists has discovered that cells are able to retain a memory of a previous perturbation within the 3D structure of their genome, independently of their DNA ...

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues. Breast cancers can be ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how ...

“We’ve long known that mutations drive cancer,” said Dr. Martin Rivas, a cancer researcher at Sylvester Comprehensive Cancer Center. “But this work shows that architecture—the way DNA folds—can be ...

CHICAGO --- In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation. Retrotransposons ...

The origin of eukaryotes -- Genome size and organismal complexity -- The human genome -- Why population size matters -- Three keys to chromosomal integrity -- The nucleotide composition landscape -- ...

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services. That's what happens inside cells ...