One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules ...

A new paper in Science Advances details how scientists have succeeded in mapping a central part of the immune system – the HLA class II molecules – while accurately predicting how they display ...

To allow the body to engage with foreign invaders, the immune cells recognize proteins which activate an immune response. These proteins are known as ‘antigens’ and are presented to immune cells that ...

Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used ...

This paper is the first description of the three-dimensional structure of a class II human leukocyte antigen (HLA). Also known as histocompatibility antigens, the HLA molecules are present on various ...

Human LAG-3 homodimer (with domains D1, D2, D3 and D4) binding to two separate HLA-II (MHC-II) molecules on the surface of an antigen-presenting cell (APC), imposing a distinct 38° offset angle. This ...

In a breakthrough cancer therapy development, scientists at MIT and Harvard Medical School created a new way of designing ...

Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells. Typically, several molecules restrain the ability of T cells ...