DNA topoisomerases play a pivotal role in the regulation of cell division. Inhibition of Leishmania spp. topoisomerases represents an alternative to control parasite growth. Cancer research led to the ...

This is a preview. Log in through your library . Abstract The traditional treatment of infections produced by the obligate intramacrophage protozoan Leishmania donovani involves the use of antimonial ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, ...

Panel A shows fleshy swelling of the lip, gum, and floor of the mouth. Panel B shows the excellent response to treatment. Panel C shows the results of a PCR assay: lane M contains a DNA ladder, 100 bp ...

Leishmaniasis, a parasitic disease transmitted by sand flies, has long challenged veterinarians and public health experts alike. Found in humans and animals across Israel and many other parts of the ...

A disfiguring parasitic infection, common in the tropics, has now found a home in Texas and Oklahoma and is expanding its range in the U.S. The parasite, Leishmania mexicana, is transmitted by tiny ...