The American Journal of Managed Care

Bepirovirsen Acts as a Functional Cure in Phase 3 Trials

Functional cure required HBV DNA <LLOQ and undetectable HBsAg for ≥24 weeks off all therapy, achieved in 127/650 and 106/570 bepirovirsen-treated patients (P<.001). Lower baseline HBsAg (≤1000 IU/mL) ...
Hoodline

Bepirovirsen Shows Promise As Functional Cure For Hepatitis B

Bepirovirsen achieved functional cures in about 1 in 5 patients in global trials; FDA review is set for Oct. 26, 2026.
Healthline

How Does Wegovy Work?

The mechanism of action of Wegovy (how it works) may vary depending on the indication(s) for which it is prescribed. Here is what experts know about Wegovy’s mechanism of action for its approved uses.
Business Wire

Ionis partner GSK announces bepirovirsen accepted for Priority Review and granted Breakthrough Therapy Designation by U.S. FDA as a potential first-in-class medicine for ...

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner GSK today announced the U.S. Food and Drug Administration (FDA) has accepted for Priority Review the New Drug ...
Fierce Biotech

GSK’s hepatitis B drug cures one-fifth of patients in ‘major step’ for pervasive disease

After treatment with bepirovirsen, however, 19% of patients achieved the strictly defined “functional cure” criteria. For the ...