T cells are central to adaptive immunity, orchestrating targeted responses against infections and malignancies while forming a durable immunological memory. Memory T cells, particularly CD8+ subsets, ...

Scientists uncover a new “recipe” that shows how exhausted T cells can be reprogrammed to regain their ability to attack tumors.

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...

Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less able to mount a strong antiviral response, revealing how nutrition can shape ...

Georgetown University's Lombardi Comprehensive Cancer Center researchers have identified a new way to reprogram T cells, which are infection and tumor-fighting white blood cells, so that they have a ...

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...

Scientists have discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

When killer T cells of our immune system divide, they normally undergo asymmetric cell division (ACD): Each daughter cell inherits different cellular components, which drive the cells toward divergent ...

This image shows killer T cells surrounding and attacking a cancer cell. A new atlas developed by researchers at UC San Diego could make it possible to design custom T cells for immunotherapy to ...