A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in the ...

NMDA receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission and underpin synaptic plasticity, learning and memory. Their unique voltage-dependent block by magnesium and ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

The research team at the Institute for Basic Science (IBS) has presented a new therapeutic strategy that could improve the ...

Treatment-resistant depression presents a substantial clinical challenge, with patients failing to respond adequately to conventional antidepressants. Converging evidence implicates dysregulation of N ...

A new study reveals that targeting the SLC6A20 glycine transporter with ASOs restores NMDAR function and reverses adult autism behaviors.

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Researchers have identified a promising new therapeutic strategy for autism spectrum disorder (ASD). A research team led by ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...