Gene expression governs whether neuroblastoma tumor cells exist in either the adrenergic (differentiated and sensitive to treatment) or mesenchymal (less differentiated and therapy-resistant) cell ...

Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. Scientists resolved the mystery, showing the drug 'hijacks' a normal ...

Childhood neuroblastoma is often a fatal disease. Despite initial treatment success, most patients relapse or develop resistance to the current therapies. A new approach using a combination of two ...

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10 ...

(L to R) Co-first and co-corresponding author Min Pan, PhD, co-first author Yinwen Zhang, PhD, St. Jude Department of Computational Biology, co-corresponding author John Easton, PhD, St. Jude ...