In women with intrahepatic cholestasis of pregnancy (ICP), higher peak bile acid levels and elevated maternal BMI (24.6) were associated with an increased risk for pruritus severity deterioration as ...
Credit: Mirum Pharmaceuticals. The approval was based on data from the phase 3 MARCH-PFIC trial. The Food and Drug Administration (FDA) has approved Livmarli ® (maralixibat) for the treatment of ...
Cholestasis is characterized by the accumulation of bile acids (BAs) in the liver and is often associated with severe itching (cholestatic pruritus (CP)). Activation of the GPCR hX4 in dorsal root ...
- FDA approval based on MARCH Phase 3 study with highly statistically significant (p<0.0001) reduction in pruritus severity between LIVMARLI vs. placebo FOSTER CITY, Calif.--(BUSINESS WIRE)--Mirum ...
In a cohort of 104 patients with intrahepatic cholestasis of pregnancy (ICP), 44% experienced recurrence in subsequent pregnancies, with peak total bile acid levels > 40 μM/L in the index pregnancy ...
Citrin deficiency is an autosomal recessive disorder arising from mutations in the SLC25A13 gene. The deficiency impairs the mitochondrial aspartate–glutamate carrier, which is a key component of the ...
Effects of COVID-19 quarantine on outcomes in individuals with intrahepatic cholestasis of pregnancy
A recent study published in Frontiers in Medicine evaluated the effects of coronavirus disease 2019 (COVID-19) quarantine on outcomes in individuals with intrahepatic cholestasis of pregnancy (ICP).
FOSTER CITY, Calif.--(BUSINESS WIRE)--Mirum Pharmaceuticals, Inc. (NASDAQ: MIRM) today announced that the U.S. Food and Drug Administration (FDA) has extended the review of the Supplemental New Drug ...
Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug ...
A global study reveals that cutting-edge cancer immunotherapies, while lifesaving, carry a hidden risk: they may trigger cholestasis, a serious liver condition where bile flow stalls. Analyzing 634 ...
Please provide your email address to receive an email when new articles are posted on . Stillbirth rates were lower among women with intrahepatic cholestasis of pregnancy vs. women without. Women with ...
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