Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators used a genetic sequencing technique called whole exome sequencing to discover a new rare ...
Transformed SCLC from EGFR-mutated LUAD shows a unique mutational profile, complicating treatment approaches and highlighting the need for tailored therapies. Whole exome sequencing revealed ...
Polygenic scores (PRSs) are derived by summing genome-wide genetic variants associated with a given trait or disease. As aggregates of genetic variants’ effects, they are used to predict disease risk.
Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...
Understanding Bioinformatics Workflows for NGS Analysis: Case Study with Whole-exome Sequencing Data
NGS enables the in-depth analysis of the genome and the identification and investigation of disease-associated variants–especially when workflows include target enrichment, which focuses on specific ...
Survival outcomes of patients with de novo stage metastatic head and neck cancer: A single center experience. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does ...
Indefinite versus 2 years fixed duration of immune checkpoint inhibition in metastatic non–small cell lung cancer. This is an ASCO Meeting Abstract from the 2026 ASCO Annual Meeting I. This abstract ...
Based on single-stranded DNA library method, we established an efficient workflow to parallelly construct targeted genomic and epigenomic sequencing libraries from a small amount of DNA. We applied ...
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