Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

The 49ers scored a touchdown on their opening series of the preseason, then their defense crumbled by halftime against the ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

Discover the top breakout running backs for 2025 fantasy football drafts, including Jordan Mason, Isaac Guerendo, and Omarion ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

Jawhar Jordan and Isaac Guerendo combined to anchor a surprisingly stout run game during Jeff Brohm's inaugural season as the head coach of the Cardinals, but both backs were selected in the 2024 NFL ...

In the fourth quarter, Guerendo departed with a foot injury and Shanahan said the 49ers were gathering information and hoping for the best. “I thought Isaac looked real good today,” Shanahan said.

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.