More than one-third of the elevated serum proteins reflected muscle fiber damage and leakage into the bloodstream. A large, reproducible set of blood-based protein biomarkers can reliably distinguish ...

Almost all (97%) of the patients with positive planar imaging and positive single-photon emission computed tomography findings were diagnosed with ATTR-CM. Single-photon emission computed tomography ...

Patients with ATTR-CM who experienced outpatient worsening heart failure had a 2.5-fold increased risk of mortality compared with those who did not. Outpatient worsening heart failure is an ...

The median time to reach a diagnosis of ATTR-CM from the time of heart failure diagnosis was 490 days (1.3 years). There are clinically important delays between the incidence of heart failure and the ...

Patients reported higher habitual levels of physical activity following the PR intervention, shifting from low to moderate activity levels. A 12-month supervised program of pulmonary rehabilitation ...

Patients with PAH who experience low levels of oxygen may have a poor quality of life, and vital organs may be compromised if these levels are not corrected. 6 Oxygen therapy can help patients ...

Individuals with advanced liver disease may also experience significant weight loss due to nausea and poor appetite. Candidates for liver transplantation may need to gain weight to optimize surgical ...

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired autoimmune neurological disorder in which both T-cell-mediated and humoral immune mechanisms target healthy myelinated ...

A systematic review and meta-analysis of trials in CIDP was published in 2023, studying the outcomes of patients including at least 2 years of follow-up. Studies conducted over 1 to 2 years ...

Coramitug is well tolerated and leads to a statistically significant reduction in N-terminal pro-brain type natriuretic peptide (NT-proBNP)—a marker of disease progression in transthyretin-mediated ...

More than half (56.3%) of the patients with PBC treated with seladelpar as a second-line therapy achieved a biochemical response. The efficacy of seladelpar as a second-line therapy in patients with ...

Long-term ruxolitinib use may lead to invasive fungal sinusitis, according to a new case study published in the Journal of Medical Case Reports. “Surgical treatment in combination with antifungal and ...