Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.
Researchers at Weill Cornell Medicine report that a rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells in a preclinical study.
Evaluating the immune landscape in early onset colorectal cancer patients. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.
The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses. However, despite strong ...
Sepsis, a critical condition characterized by life-threatening organ dysfunction, arises from a dysregulated host response to infection. The resultant immunosuppression constitutes the primary ...
cGAS-STING signaling exerts antitumor functions in cancer cells in an autonomous and non-autonomous manner. On the one hand, OIS secretes SASP in response to oncogenic stimuli to prevent cell ...
The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...
A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell ...
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