Gut

Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment

The gut microbiota plays a crucial role in regulating host immunity, metabolism and inflammation, with accumulating evidence ...
Gut

Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection

In chronic hepatitis B virus (HBV) infection, the central debate remains whom and when to treat. The 2025 European Association for the Study of the Liver (EASL) Clinical Practice Guidelines (CPGs)1 ...
Gut

Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study

Background Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a ...
gut.bmj

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Objective In the tumour microenvironment, critical drivers of immune escape include the oncogenic activity of the tumour cell-intrinsic osteopontin (OPN), the expression of programmed death ligand 1 ...
gut.bmj

Development and validation of the Nancy histological index for UC

2 Inserm U954, Genetic Nutrition and Exposure to Environmental Risks (NGERE), University of Lorraine, Vandoeuvre- lès-Nancy, France Correspondence to Professor Laurent Peyrin-Biroulet, Inserm U954 and ...
gut.bmj

Association between appendectomy and Parkinson’s disease from the UK Biobank

2 Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China Correspondence to Dr Changhe Shi, Department of ...
gut.bmj

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

Objective Butyrate exerts metabolic benefits in mice and humans, the underlying mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite and energy expenditure, and ...
gut.bmj

Dyspepsia and the microbiome: time to focus on the small intestine

3 School of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia Correspondence to Dr Erin R Shanahan, Gastroenterology Research, Level 5, ...
gut.bmj

Accuracy of screening for gastric cancer using serum pepsinogen concentrations

Professor M A Fujino, First Department of Medicine, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi 409-38, Japan. BACKGROUND/AIMS The characteristics of pepsinogen ...
gut.bmj

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

Objective The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk of relapse and virological ...
gut.bmj

Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men

Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link between red meat intake and poor cardiometabolic health. We investigated whether gut microbiome could modify ...
gut.bmj

Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use

Background Surveillance colonoscopy after polyp removal is recommended to prevent subsequent colorectal cancer (CRC). It is known that advanced adenomas have a substantially higher risk than ...