The EMBO Journal

The functional significance of mitochondrial respiratory chain supercomplexes

This month's cover highlights the article The two‐step cargo recognition mechanism of heterotrimeric kinesin by Xuguang Jiang, Tadayuki Ogawa, Nobutaka Hirokawa and colleagues. The cover illustrates ...
The EMBO Journal

The structure of fly Teneurin‐m reveals an asymmetric self‐assembly that allows expansion into zippers

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Teneurins are conserved cell adhesion ...
The EMBO Journal

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells

This month's cover highlights the article Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM‐1 by Max Grönloh, Janine Arts, Jaap van Buul and ...
The EMBO Journal

Once in a lifetime

Most senior scientists who have carved out a career in science eventually look back at how they managed to get there. Many may feel that their position is a just reward for their hard work and ...
The EMBO Journal

Structural basis for conformational switching and GTP loading of the large G protein atlastin

Atlastin, a member of the dynamin superfamily, is known to catalyse homotypic membrane fusion in the smooth endoplasmic reticulum (ER). Recent studies of atlastin have elucidated key features about ...
The EMBO Journal

Stoichiometry of the T‐cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum

The T‐cell receptor (TCR)–CD3 complex is critical for T‐cell development and function, and represents one of the most complex transmembrane receptors. Models of different stoichiometry and valency ...
The EMBO Journal

The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation

Naïve T helper (Th) cells differentiate in response to antigen stimulation into either Th1 or Th2 effector cells, which are characterized by the secretion of different set of cytokines. Th2 ...
The EMBO Journal

Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. CD8 + T cells have critical roles in tumor ...
The EMBO Journal

TRAF6‐mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

Figure 3. NRIF is polyubiquitinated by the E3 ubiquitin ligase TRAF6. HEK 293 cells were cotransfected with Flag‐NRIF, Flag‐TRAF6 or HA‐ubiquitin, then lysed in SDS lysis buffer and the lysates were ...
The EMBO Journal

A new plant protein interacts with eIF3 and 60S to enhance virus‐activated translation re‐initiation

Here, we used CaMV–TAV as a tool to fish for cellular proteins that could function in the activation of polycistronic mRNA translation. We report a new plant protein—‘Re‐Initiation Supporting Protein’ ...
The EMBO Journal

Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes

The TREX complex is involved in both transcription elongation and mRNA export and is recruited to nascent transcription complexes. We have examined Yra1p, Sub2p and Hpr1p recruitment to nine genes of ...
The EMBO Journal

Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor

Department of Microbiology and Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL, 35294-3300 USA ...