The iSNP systems genomics pipeline models how non-coding SNPs cumulatively impact cellular signalling and gene regulatory networks, revealing patient-specific mechanisms linking disease-associated ...

Both microtubule-binding protein tau and RNA-binding protein TDP-43 have been associated with neurodegenerative diseases, such as Alzheimer’s disease, including in co-pathological deposition with each ...

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...

AdipoR1 selectively recognizes adipokine ligands, differentially shaping T-cell immune outcomes. CTRP9 engages AdipoR1 to ...

Keap1 is a BTB‐Kelch substrate adaptor protein that regulates steady‐state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The compositional perturbation autoencoder ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Centrosomes are tubulin-based organelles that ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The HSP110/HSP70 chaperone system plays key ...

A plethora of endocrine disrupting chemicals (EDCs)—omnipresent in food, household, and personal care products—interfere with various human sperm functions and thus might impair fertilization.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gli1 + chondrogenic progenitors maintained by ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chemical and genetic perturbations, such as ...

As a proof of principle Bonnay et al (2020) started by investigating if Brat tumors have a metabolic profile that is different from normal brains. Using transcriptome data of both Brat‐depleted and ...