The cellular microenvironment is a powerful regulator of the cell state and function. Both biochemical and morphophysical environmental cues have been shown to profoundly influence cellular decisions.

Introduction: Tissue elasticity is essential to proper cell biology and organ function including the heart. Cell culture models on rigid polystyrene dishes are limited in studying the impact of tissue ...

Macrophages are essential immune cells involved in pathogen clearance, initiation and resolution of inflammation, and tissue repair across multiple organ systems. They exhibit remarkable phenotypic ...

A protein from the body’s immune cells may secretly worsen heart damage after a heart attack. Scientists found it plays a surprising role in triggering dangerous heart rhythms. Credit: Shutterstock ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During gastrulation, mesodermal cells derived ...

Contributed by Elliot L. Elson; received June 9, 2025; accepted August 29, 2025; reviewed by Baohua Ji, M. Taher A. Saif, and Assaf Zemel ...

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Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL. (T.P., L.L., C.-K.S., M.W., H.-Y.L., Y.H., E.T ...