Defects in elastin trigger hyperproliferation of smooth muscle cells, which leads to arterial and congenital heart diseases. Research now shows that elastin deficiency induces SPHK1 and S1P signaling ...

Human mutations in Notch signalling components have been implicated in several forms of congenital cardiovascular disease, including cardiac outflow tract defects (jagged 1, notch 2), aortic valve ...

You will be redirected to our submission process. Patent Foramen Ovale (PFO) is a common congenital cardiac anatomical variant present in approximately 25% of the general population. While its ...