ESPN's FPI simulation projects how the 49ers finish the 2025 season, their playoff seed, and how far San Francisco advances.

Monday, 8:15 p.m. EST, ESPN. NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead 27-18.

Help is on the way at running back. Injuries have sidelined Alvin Kamara, Kendre Miller, and Devin Neal, so the Saints signed Nyheim Hines.

Here's where the Texans stack up in FPI ratings entering their Week 16 showdown against the Las Vegas Raiders on Sunday ...

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

Right now, the Indianapolis Colts are trying to see how much gas 44-year-old Philip Rivers has left in the tank. […] ...

ESPN insider evaluates the Buffalo Bills’ Super Bowl outlook while warning that the surging Houston Texans could threaten ...

The Steelers and Colts aren't created equally here, though. Assuming the Colts re-sign Jones after his injury, he'll be ...

Here's the latest heading into NFL Week 16, including intel on Patrick Mahomes, Micah Parsons, Philip Rivers, playoff races ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

Who is playing on Monday Night Football? Check out the complete MNF game schedule, including 49ers vs Colts matchup for NFL Week 16 game on Dec. 22.

On a six-game win streak, are the Texans among the top five teams in the NFL entering Sunday afternoon's bout against the ...