The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

The 49ers scored a touchdown on their opening series of the preseason, then their defense crumbled by halftime against the ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

The Radcliff, Ky. native was a wide receiver coming out of North Hardin. LOUISVILLE, Ky. - As fans of the Louisville football program know at this point, the Cardinals have an embarrassment of riches ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The 49ers are facing the Broncos in their first preseason game. Here are fiveplayers fans should keep their eyes on during ...

No team has suffered more injuries to the running back position than the San Francisco 49ers in recent years. Rookie RB Jordan James is the latest to suffer a serious injury in the San Francisco backf ...

• With Kevin Givens (pectoral), Evan Anderson (knee) and Jordan Elliott (back) out of action, the 49ers signed defensive ...

When Kyle Shanahan has been asked about an injured player this summer, the San Francisco 49ers head coach has offered a ...

What are three things we want to see from today's joint practice between the Denver Broncos and San Francisco 49ers?

“Jordan James broke his finger, so he’s getting surgery on that,” Shanahan said, via David Bonilla of 49erswebzone.com.

Farrell won't light up the box score, but he's brought exactly what the Niners were hoping for when they signed him.