The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

The San Francisco 49ers signed running back Ke’Shawn Vaughn to a one-year deal ahead of their first preseason game against the Denver Broncos. Vaughn signed with the 49ers’ practice squad in August ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

Vaughn will solidify the 49ers' backfield depth with Isaac Guerendo (shoulder) and Jordan James (finger) both sidelined for a few weeks. Vaughn spent most of the 2024 season on the 49ers' practice ...

The 49ers are facing the Broncos in their first preseason game. Here are fiveplayers fans should keep their eyes on during ...

When Kyle Shanahan has been asked about an injured player this summer, the San Francisco 49ers head coach has offered a ...

What are three things we want to see from today's joint practice between the Denver Broncos and San Francisco 49ers?

What’s changed: Healthy since early in the offseason, McCaffrey predictably earned raves for his spring work. Coach Kyle ...

Injuries have been running rampant on the San Francisco 49ers since training camp began. They can’t even continue their kicker competition or have three quarter ...

Jake Moody has won the San Francisco 49ers' kicking competition. SANTA CLARA, Calif (AP) — Jake Moody has won the San ...

Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...