BMJ

Paracetamol and cyclooxygenase inhibition: is there a cause for concern?

1 Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany 2 Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University ...
BMJ

A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing

GI Motility Program, Divisions of Gastroenterology and Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, CSMC Burns & Allen Research Institute, Los Angeles, California 90048, School ...
BMJ

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

Objectives To examine the safety and efficacy of rontalizumab, a humanised IgG1 anti-interferon α (anti-IFN-α) monoclonal antibody, in patients with moderate-to-severe systemic lupus erythematosus ...
BMJ

Gout: why is this curable disease so seldom cured?

3 Department of Rheumatology, University of Edinburgh, Centre for Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK 4 Department of Medicine, Rheumatology Section, Alicante ...
BMJ

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

2 Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska Hospital, Stockholm, Sweden 3 Unit of Clinical Immunology, Uppsala University/Akademiska Sjukhuset, Uppsala, Sweden 4 ...
BMJ

Withdrawal of low-dose prednisone in SLE patients with a clinically quiescent disease for more than 1 year: a randomised clinical trial

1 Sorbonne Université, Assistance Publique–Hôpitaux de Paris, Groupement Hospitalier Pitié–Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody ...
BMJ

Clinically important changes in individual and composite measures of rheumatoid arthritis activity: thresholds applicable in clinical trials

Correspondence to Dr Michael M Ward, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, NIAMS/NIH, Building 10 CRC, Room ...
BMJ

Psoriatic arthritis: epidemiology, clinical features, course, and outcome

1 University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, ...
BMJ

Studies with pain rating scales.

Good correlation has been shown between pain scores derived from 4 different rating scales. The correlation was maintained when presentation of the scales was separated by a series of questions and by ...
BMJ

Gout is associated with more comorbidities, poorer health-related quality of life and higher healthcare utilisation in US veterans

Center for Chronic Disease Outcomes Research at the VA Medical Center, Minneapolis, Minnesota, USA Objective: To better understand the impact of gout on functional status, health-related quality of ...
BMJ

Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome highlight T cell-initiated autoimmunity

Objectives Familial aggregation of primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and co-aggregation of these autoimmune diseases (ADs) (also called ...
BMJ

The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice

Background: Randomised controlled trials (RCTs) evaluating the efficacy of antagonists to tumour necrosis factor α (TNFα) showed high response percentages in the groups treated with active drugs.