The EMBO Journal8h
LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche
LATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro ...
The EMBO Journal1d
Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders
This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...
The EMBO Journal5d
Mitochondrial DNA removal is essential for sperm development and activity
Mitochondrial DNA (mtDNA) is actively removed during spermatogenesis in a conserved process that enforces the uniparental ...
The EMBO Journal7d
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. One way cells control the speed and ...
The EMBO Journal8d
Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Changes in gut microbiota composition have ...
The EMBO Journal8d
HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The SCF (SKP1/CUL1/F-box protein) ubiquitin ...
The EMBO Journal11d
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ferroptosis, an iron-dependent form of ...
The EMBO Journal7d
Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common cause of liver cirrhosis, ...
The EMBO Journal7d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
Glioblastoma is one of the most treatment-resistant and lethal cancers, with a subset of self-renewing brain tumour stem cells (BTSCs), driving therapy resistance and relapse. Here, we report that ...
The EMBO Journal6d
Coordination between ESCRT function and Rab conversion during endosome maturation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The endosomal pathway is essential for ...
The EMBO Journal7d
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Monoallelic loss of PTEN and ARID1A is ...
The EMBO Journal8d
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Mitochondrial DNA (mtDNA) replication is ...