EMBO Press

From microscopes to maps: enabling a new era of open and reproducible data sharing in intravital imaging

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...
EMBO Press

Closing the loop on EGFR therapy: decoding cetuximab response through circ-EGFR

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
The EMBO Journal

PerturbNet predicts single-cell responses to unseen chemical and genetic perturbations

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chemical and genetic perturbations, such as ...
The EMBO Journal

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

A progressive loss of neurons with age underlies a variety of debilitating neurological disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), yet few effective ...
The EMBO Journal

ER-phagy restrains inflammatory responses through its receptor UBAC2

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...
The EMBO Journal

The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The HSP110/HSP70 chaperone system plays key ...
The EMBO Journal

STINGing organelle surface with acid

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway has emerged as a critical driver of inflammation in a variety of settings, such as virus infection, ...
The EMBO Journal

Tumor start‐up: mitochondrial fusion makes it happen

As a proof of principle Bonnay et al (2020) started by investigating if Brat tumors have a metabolic profile that is different from normal brains. Using transcriptome data of both Brat‐depleted and ...
The EMBO Journal

Crystal structure of auxin‐binding protein 1 in complex with auxin

The structure of auxin‐binding protein 1 (ABP1) from maize has been determined at 1.9 Å resolution, revealing its auxin‐binding site. The structure confirms that ABP1 belongs to the ancient and ...
The EMBO Journal

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, ...
The EMBO Journal

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The EMBO Journal

Reconstitution reveals the functional core of mammalian eIF3

Eukaryotic translation initiation factor (eIF)3 is the largest eIF (∼650 kDa), consisting of 10–13 different polypeptide subunits in mammalian cells. To understand the role of each subunit, we ...