The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

Week 16 of the NFL season features some games with massive playoff implications, and the first one on the ledger occurred ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

Seattle Seahawks running back Kenneth Walker II corkscrews off a Los Angeles Ram for a 17-yard gain on third down during Week ...

As the number of teams competing for playoff spots begins to dwindle, those that will make field are jockeying in for top ...

Our Rams vs. Seahawks picks, odds & expert predictions for Thursday Night Football on December 18, 2025 have Los Angeles ...

Professional sports bettors and handicappers make predictions on NFL Week 16 games and College Football Playoff first-round ...

Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on ...

According to SportsLine's Inside the Lines team, Indianapolis on Monday night has much more to lose in Week 16 ...

With such a big game taking place under the bright lights of Thursday Night Football, our Rams vs. Seahawks predictions ...

In a battle for first place in the NFC West and the No. 1 seed, the LA Rams visit the Seattle Seahawks Thursday night.

The Colts desperately need a win in Week 16 against the 49ers. Here are 3 Colts bold predictions before their huge MNF game.