· si-544 is the first highly potent and selective Kv1.3 blocker to safely achieve patient plasma levels suitable for high target engagement · Excellent safety and tolerability consistent with prior ...
The authors investigated the mechanisms underlying the pause in striatal cholinergic interneurons (SCINs) induced by thalamic input, identifying that Kv1 channels play a key role in this ...
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Although the underlying mechanisms have historically remained shrouded in mystery, new findings from the ...
Anu Tyagi, Tofayel Ahmed, Shi Jian, Saumya Bajaj, Seow Theng Ong, Stephanie Shee Min Goay, Yue Zhao, Igor Vorobyov, Changlin Tian, K. George Chandy, Shashi Bhushan Proceedings of the National Academy ...
VRG Therapeutics reaches monthly dosing for its lead program targeting Kv1.3 for the treatment of atopic dermatitis and other chronic inflammatory diseases. This development holds the promise of being ...
Phenotypic modulation of vascular smooth muscle cells has been associated with a decreased expression of all voltage-dependent potassium channel (Kv)1 channel encoding genes but Kcna3 (which encodes ...
The nomination of novel Lp-PLA2 inhibitor DPT0415 for the treatment of DR & DME. DPT0415 is a highly potent, selective and safe Lp-PLA2 inhibitor with sufficient target engagement at a dose of 0.3 mpk ...
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