First disclosure of a novel mechanism of action for the degradation of TEAD by selectively inducing its proximity to FBXO22 as a targeted molecular glue, leading to strong and rapid degradation of ...

Wegovy is a glucagon-like peptide-1 (GLP-1) receptor agonist prescribed for weight loss, to reduce the risk of serious cardiovascular problems, and to treat a serious liver problem called ...

This study presents valuable findings with practical and theoretical implications for drug discovery, particularly in the context of repurposing cipargamin CIP for the treatment of Babesia spp. The ...

Researchers headed by teams at Michigan Medicine and Mayo Clinic have discovered how a molecular process that occurs when donor hearts are preserved in cold storage contributes to failure after ...

Merus N.V., an oncology-focused company, announced the publication of research on petosemtamab, a bispecific antibody targeting EGFR and LGR5, in the journal "Cancers." The study highlights the ...

A real-world study finds reduced RAASi-related hyperkalemia risk among at-risk patients initiating SGLT2 inhibitors. Sodium glucose cotransporter 2 inhibitor (SGLT2i) use is associated with lower ...

ABSTRACT: Juvenile Myoclonic Epilepsy (JME) is a prevalent form of generalized epilepsy, predominantly affecting adolescents and young adults. It is characterized by myoclonic seizures, grand mal ...

Platinum(II) complexes such as cisplatin, among a few others, are well-known anticancer metal-based drugs approved for clinical use. In spite of their wide acceptance, the respective chemotherapy is ...

Death risk doubled for patients experiencing early hyponatremia after starting a thiazide diuretic. Patients who experience hyponatremia soon after starting thiazide diuretics have an increased risk ...

"I think [gepotidacin] gives a different side effect profile available to the clinicians, and I think for patients as well, it provides a better, more durable option over time," says Ryan Haumschild, ...

Estrogen therapy is linked to increased risks of BCC, cSCC, and cM, with higher doses correlating with greater risk. Loop diuretics and thiazide diuretics are associated with increased risks of cSCC ...