Amid a handful of injuries in their running back room, the San Francisco 49ers are bolstering their backfield.

Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The San Francisco 49ers cannot last more than a few months without losing their entire running back room to injury, even in ...

The San Francisco 49ers could use more capable running backs on their roster and signing Jeff Wilson Jr. gives them another.

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

Discover the top breakout running backs for 2025 fantasy football drafts, including Jordan Mason, Isaac Guerendo, and Omarion ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

Stats and projections for Isaac Guerendo in fantasy football, including ADP, insights, and 2025 outlook, as the San Francisco ...

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.

In the fourth quarter, Guerendo departed with a foot injury and Shanahan said the 49ers were gathering information and hoping for the best. “I thought Isaac looked real good today,” Shanahan said.