Amid a handful of injuries in their running back room, the San Francisco 49ers are bolstering their backfield.

Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

Given Shanahan’s success in turning undrafted running backs into productive players at the highest level, it is probably ...

Discover the top breakout running backs for 2025 fantasy football drafts, including Jordan Mason, Isaac Guerendo, and Omarion ...

If 49ers are to hit the ground running on Sept. 7, these eight plays must be protected until the regular season begins.

The San Francisco 49ers cannot last more than a few months without losing their entire running back room to injury, even in the preseason. With multiple key players back on the shelf, the 49ers added ...

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.