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The Clinical COPD Questionnaire: response to pulmonary rehabilitation and minimal clinically important difference

Background The Clinical COPD Questionnaire (CCQ) is a simple 10-item, health-related quality of life questionnaire (HRQoL) with good psychometric properties. However, little data exists regarding the ...
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S74 Improved NIV adherence with intelligent volume assured pressure support with automatic expiratory positive airway pressure (iVAPS-AE) in amyotrophic lateral sclerosis (ALS)

Introduction Few studies have compared adherence rates between volume mode non-invasive ventilation (NIV) and pressure mode (ST) NIV in amyotrophic lateral sclerosis (ALS). The use of intelligent ...
Thorax

Maternal BMI and smoking partly explain the association between maternal socio-economic position and offspring asthma

Background Numerous studies have found associations between parental socio-economic position (SEP) and offspring asthma.
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Symptoms and the early diagnosis of lung cancer

Thoracic Oncology Unit, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK Correspondence to: Dr M D Peake Thoracic Oncology Unit and Institute for Lung Health, Department of ...
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Is late diagnosis of lung cancer inevitable? Interview study of patients’ recollections of symptoms before diagnosis

Background: A study was undertaken to explore the pathway to diagnosis among a group of patients recently diagnosed with lung cancer. Methods: A directed interview study triangulating patients’ ...
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Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection

1 Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK 2 Department of Infectious Diseases, Royal Free Hospital, London, UK 3 Department of Primary Care and Population Sciences, ...
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COPD exacerbations · 1: Epidemiology

The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is reviewed with particular reference to the definition, frequency, time course, natural history and seasonality, and ...
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Understanding lung disease following extremely preterm birth

Individuals born extremely preterm (EP-born) must complete lung development outside the uterus, affecting the maturation and growth of airways and alveoli. They often show signs of both obstructive ...
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COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis

1 Institute of Occupational and Environmental Medicine, School of Population and Health Sciences, University of Birmingham, Birmingham, UK 2 Division of Applied Health Sciences, University of Aberdeen ...
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S90 FRONTIER-3: a randomized, phase 2a study to evaluate the efficacy and safety of tozorakimab (an anti-interleukin-33 monoclonal antibody) in early-onset asthma

2 Research and Early Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 3 Respiratory and Immunology, Biometrics and Statistical Innovation, Late Respiratory ...
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Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease

BACKGROUND Chronic cough is associated with an increased sensitivity to inhaled capsaicin in a number of conditions but there are no data for patients with more severe asthma or chronic obstructive ...
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Association between obesity and asthma in 4–11 year old children in the UK

BACKGROUND There is evidence of a positive association between asthma and obesity in adults and in children. We investigated, in a large sample of English and Scottish primary school children, whether ...