Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

Fungal infections and autoimmunity share a complex, bidirectional relationship that significantly impacts patient outcomes. Emerging evidence highlights how fungal pathogens contribute to autoimmune ...

Neural stem cell (NSC) function in mammalian brains declines during aging, but the molecular mechanisms involved remain ill-defined. Here, integrated multi-omics reveals continuous alterations of ...

De novo protein design is of fundamental interest to synthetic biology, with a plethora of computational methods of various degrees of generality developed in recent years. Here, we introduce ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002). MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

A previous study showed that the predominant macrophage population during the mid-stage of skin wound healing (3–5 days post-injury) expresses CD206 and can be further divided into CD301b-positive and ...

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Facundo D. Batista (Chief Editor) Facundo is the Phillip T. and Susan M. Ragon Professor of Microbiology and Immunology at Harvard Medical School, and Associate Director of the Ragon Institute of MGH, ...

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TP53 -mutant acute myeloid leukemia/myelodysplastic neoplasms (AML/MDS) are distinct clinicogenomic entities characterized by chemotherapy resistance, high relapse rates, and poor survival. Chimeric ...

Influenza A virus (IAV) infection triggers derepression of host transposable elements (TEs), which have the potential to form double-stranded (ds)RNAs and could enhance innate antiviral immunity.