Demi Moore, who is nominated for Best Actress at the 2025 Oscars, and Margaret Qualley, who plays a younger version of Moore's character in Coralie Fargeat's horror film 'The Substance,' each put their bodies on the line for the demanding shoot.

Demi Moore thought her four-decade Hollywood career might be over a few years ago. The actress, 62, battled negative thoughts about herself after a producer dismissed her as a "popcorn actress."

He thinks her performance had substance. Dennis Quaid, who starred in the 2025 Oscar-nominated film “The Substance” with Demi Moore and Margaret Qualley, is confident that Moore will win big at the Academy Awards on Sunday.

At 62, Demi Moore is poised to win her first Academy Award for her powerful performance in The Substance, a film that revitalised her career and reflected her personal struggles with self-worth in Hollywood.

In the coming-of-age film, "Now and Then," Moore played the older version of a young girl named Samantha, who together with her friends, played by Rosie O'Donnell, Rita Wilson and Melanie Griffith, recall a memorable summer they shared in 1970.

The Substance took theaters by storm, but the body horror film starring Demi Moore is not for the weak. Some viewers might prefer to watch it at home so they can take a breath and a walk around the block after witnessing French filmmaker Coralie Fargeat’s confrontational and explicit imagery.