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New Advances in the Treatment and Assessment of HPA Axis Dysfunction
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HPS axis dysregulation refers to an imbalance in the hypothalamic-pituitary-suprarenal (HPS) axis, a vital system involved in stress response, metabolism, and hormone regulation. Also commonly called the HPA (hypothalamic-pituitary-adrenal) axis, this system includes: 1. Hypothalamus - The brain’s control center that signals the pituitary gland to release hormones. 2. Pituitary Gland - Sends signals (like ACTH) to the adrenal glands. 3. Adrenal Glands (suprarenal glands) - Release stress hormone
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If you’ve tried SSRIs but still struggle with depression, there’s a deeper layer that often goes overlooked. Research shows that inflammation, HPA axis dysregulation, and the gut-brain axis play major roles in mood regulation. Chronic inflammation doesn’t just lower serotonin—it redirects it, creating neurotoxic byproducts that impair brain function, energy, and motivation. This is why depression often comes with brain fog, fatigue, and low drive, not just sadness. While SSRI’s certainly have th
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