SGLT-2 Inhibitors - Mechanism of Action
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SGLT-2 Inhibitors - Mechanism of Action
Inhibits the Na-glucose co-transporter 2 (SGLT-2) in the kidney to reduce glucose reabsorption, resulting in increased urinary glucose excretion, and lower plasma glucose. SGLT-2 is expressed in the proximal tubule and mediates reabsorption of ~90% of filtered glucose.
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